You saw it correctly. That’s not a spelling error. I meant “APO”.
If, every day you can PROTECT your “APO-A1” protein within your arteries, you will likely live a lot longer than otherwise. It’s easy to do this. It’s easy to protect your APO-A1 protein. And you’ll feel much, much better in the process. But first let’s explain a bit more about your APO-A1.
APO-A1 is the acronym, the short version, of “apolipoprotein A-I”. Here’s a very crude explanation of APO-A1: a protein that your body makes from the APOA1 gene, that, in turn is a component of the “good cholesterol”, the HDL cholesterol, (High Density Lipoprotein).
Why has the medical profession been preaching and championing for us to get our HDLs up much higher and to lower our LDLs, (Low Density Lipoprotein)?
Until recently, it was believed that it was the HDL cholesterol itself that acted like a bouncer at a nightclub, the nightclub being our arteries. If the bad cholesterol, the LDLs became too noticeable and rowdy then the good HDLs would rush in to snatch the LDLs and throw them out of the nightclub. If, on the other hand there were too many bad LDLs as to overrun your good HDLs, and it happened for years and years, then all havoc would break loose and the result would be inflamed arteries, plaques, plugged arteries, strokes, heart attacks, problems with nerves, dementia and so on.
The ability of HDLs to escort the bad LDLs out of the system is termed “EFFLUX”.
Recently, medical research developed a new hypothesis. The quantity of HDLs may not be as important as “Efflux” capacity.
A fairly recent, powerful study concluded that it is the body’s efflux capacity that is a significant BENEFICIAL factor in controlling the rampant damage caused by LDLs. Here’s an abstract of their conclusion: “Cholesterol efflux capacity from macrophages, a metric of HDL function, has a strong inverse association with both carotid intima–media thickness and the likelihood of angiographic coronary artery disease, independently of the HDL cholesterol level. (Funded by the National Heart, Lung, and Blood Institute and others.)” [Source: “Cholesterol Efflux Capacity, High-Density Lipoprotein Function, and Atherosclerosis” by Khera, Cuchel, et al. N Engl J Med 2011; 364:127-135. http://www.nejm.org/doi/full/10.1056/NEJMoa1001689 ]
HOW DO YOU PROTECT YOUR BODY’S EFFLUX CAPACITY? By protecting your APO-A1. And take special note your APO-A1 can easily be damaged.
Your APO-A1 can easily become the MONSTER IN YOUR BODY. When the APO-A1 is damaged it can turn against you.
Caldwell B. Esselstyn Jr. M.D., quoting from National Review of Cardiology, Feb. 8, 2011, explained that “Damaged APO-A1 is proinflammatory and aetherogenic”.
Here’s the particular reference in more detail: “The main component of HDL, apolipoprotein A-I (apo A-I), is largely responsible for reverse cholesterol transport through the macrophage ATP-binding cassette transporter ABCA1. Apo A-I can be damaged by oxidative mechanisms, which render the protein less able to promote cholesterol efflux…Modification of the protein components of HDL can convert it from an anti-inflammatory to a proinflammatory particle.” [Source: “HDL and cardiovascular disease: atherogenic and atheroprotective mechanisms” by Navab, Reddy, Van Lenten, Fogelman. National Review of Cardiology. 2011 Apr;8(4):222-32. Epub 2011 Feb 8. http://www.ncbi.nlm.nih.gov/pubmed/21304474 ]
Let me put Dr. Esselstyn’s comments, and that quote you just read, into my own words so I can understand what he and they are saying.
In my own words: damaged APO-A1 will switch from the good helpful side, to turn bad and to turn against us when it does turn bad. That’s not the worst of it. Not only does damaged APO-A1 join the bad side, it amplifies the strength and damage done by the bad side. Damaged APO-A1 when added to LDLs results in a SUPERVILLAIN.
There is little to no defense against that “supervillain”. You have to wait until it loses all its energy. It’s the food you eat that fuels or helps to weaken that supervillain…and one particular food: oil.
HOW DO YOU PROTECT YOUR BODY’S APO-A1? Avoid, not just reduce, but AVOID eating, drinking and cooking with oils… “…avoid ALL OILS!!” as Caldwell B. Esselstyn Jr. M.D. shouted during one of his many helpful lectures. “Avoid ALL oils!!”…”No OILS!!!”
SUMMARY: Protect your HDL’s EFFLUX capacity to nullify your bad cholesterol by protecting your APO-A1…simply, avoid all oil.